A series of silyl, germyl and alkyl substituted trifluoroacetylfurans has been synthesized under Friedel-Crafts electrophilic acylation conditions. Biological investigations have demonstrated that germyl
derivatives of trifluoroacetylfuran are more toxic than the silicon analogues. 5-Triethylgermyl-2-
trifluoroacetylfuran was the most toxic compound (LD50
11.2 mg kg-1, i.p. for white mice), 200 times more
toxic than the silicon analogue. 5-t-Butyl- and 5-trimethylsilyl-2-trifluroacetylfuran prolong the duration
of ethanol anaesthesia by 220 and 140%. 5-Triethylgermyl-2-trifluroacetylfuran exibited high anesthetic
activity in hexobarbital test (prolonged the duration by 137%). Some of compounds influenced muscle tone
and locomotor coordination parameters. 5-Triethylgermyl-2-trifluomacetylfuran exibited analgesic activity
(ED50
0.9 mg Kg−1).