Table of Contents
Metal-Based Drugs
Volume 8 (2002), Issue 5, Pages 287-291
http://dx.doi.org/10.1155/MBD.2002.287

Antibacterial Co(II) and Ni(II) Complexes of N-(2-Furanylmethylene)-2-Aminothiadiazole and Role of SO42 ,NO3 , C2O42 and CH3CO2 anions on Biological Properties

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2University of Florence, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Rm 188, Polo Scientifico, Firenze 50019-Sesto Fiorentino, Italy

Received 7 March 2002; Accepted 28 March 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Co(II) and Ni(II) complexes with a Schiff base, N-(2-furanylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The synthesized Schiff-bases act as tridentate ligands during the complexation reaction with Co(II) and Ni(II. metal ions. They possess the composition [M(L)2]Xn (where M=Co(II) or Ni(II), L=, X=NO3 , SO42 , C2O42 or CH3CO2 and n=1 or 2) and show an octahedral geometry. In order to evaluate the effect of anions upon chelation, the Schiff-base and its complexes have been screened for antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.