Table of Contents
Metal-Based Drugs
Volume 9 (2002), Issue 1-2, Pages 109-118
http://dx.doi.org/10.1155/MBD.2002.109

Antitumour and Immunomodulatory Effects of Cu(II) Complexes of Thiobenzyhdrazide

1Department of Chemistry, Banaras Hindu university, Varanasi 221 005, India
2Department of Pathology & Saskatoon Cancer Centre, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon S7N 4H4, SK, Canada

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thiiobenzyhdrazide (Htbh) and its Cu(II) complexes, [Cu(Htbh)2Cl2] and [Cu(tbh)2] were synthesized and characterized by various physicochemical studies. In vivo and in vitro antitumour activity of Htbh, [Cu(Htbh)2Cl2] and [Cu(tbh)2] has been tested. LD50 values were calculated for all the three compounds. It was observed that the antitumour effect of [Cu(Htbh)2Cl2] is maximum. Light microscopic study of the treated tumour mass demonstrated that certain cellular degradation, such as disappearance of mitotic figures, loss in cellular compactness, distortion of nucleus and disruption of cytoplasmic boundaries, takes place in the tumour region of complex treated mice. Further, tumour bearing mice administered with Cu(II) complexes showed reversal of tumour growth associated induction of apoptosis in lymphocytes.