Table of Contents
Metal-Based Drugs
Volume 8, Issue 6, Pages 329-332
http://dx.doi.org/10.1155/MBD.2002.329

Synthesis and “in Vitro” Trypanocidal Activity Evaluation of Some Organo-iron Compounds.

1LABQUIM-Núcleo de Pesquisas em Ciências Exatas e Tecnológicas da Universidade de Franca, Av. Armando Salles Oliveira, 201, Franca Z.P. 14404-600, São Paulo, Brazil
2Dept. de Química da Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, USP, Ribeirão Preto, Av. Bandeirantes s/n, Ribeirão Preto Z.P. 14040-903, São Paulo, Brazil
3Dept. de Ciências Farmacêuticas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, Av. do Caé s/n, Ribeirão Preto Z.P. 14040-903, São Paulo, Brazil
4Dept. de Ciências da Saúde da Faculdade de Cincias Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, Av. do Café s/n, Ribeirão Preto Z.P. 14040-903, São Paulo, Brazil
5Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, P.O. Box-5009, João Pessoa 58051-970, PB, Brazil

Received 8 May 2002; Accepted 16 May 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Eight organo-iron ferrocene derivatives and arenocenium salts were prepared and evaluated by “in vitro” assay against one strain of Trypanosoma cruzi (Y). Six of the eight organo-iron compounds assayed, piperazinium diferrocenoate 1, η6-(o-xylene)-η5-(cyclopentadienyl) Iron(II) hexafluorophosphate 3, η6 -(mesitylene)-η5 -(cyclopentadienyl) iron(II) hexafluorphosphate 5, η6 -(durene)-η5 -(cyclopentadienyl) iron(II) hexafluorphosphate 6, η6 -(ρ-chlorotoluene)-η5 -(cyclopentadienyl) Iron(II) hexafluorphosphate 7 and η6 -(chlorobenzene)-η5 -(cyclopentadienyl) iron(II) picrate 8 , were poorly active in the “in vitro” assays. Only two compounds 1,1'–(N-pyperidinocarbonyl) ferrocene 2(IC50=2.4μg/mL) and η6-(o-xylene)-η5(cyclopentadienyl) iron(II) picrate 4(IC50=12.08μg/mL), were more active. Thus, some of the compounds are promising to be used against Chagas' disease as a prophylactic agents.