Table of Contents
Metal-Based Drugs
Volume 9 (2002), Issue 1-2, Pages 1-8
http://dx.doi.org/10.1155/MBD.2002.1

Bio-Inorganic Studies on the Fe(II) Sparfloxacin Complex

1Department of Chemistry, Dr. Harisingh Gour University, Sagar 470 003, MP, India
2Department of Pharmaceutical Science, Dr. Harisingh Gour University, Sagar 470 003, MP, India

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The qualitative and quantitative analysis of an antibiotic drug, 5-amino-1 cyclopropyl-7 (cis-3, 5 dimethyl-1-piperazyl)-6,8- dihydro-1, 4 dihydro-4-oxo-3-quinoline carboxylic acid (Sparfloxacin, SFX) and its pharmaceutical formulation i.e.sparx-100 tablet, has been done using polarographic and amperometric methods. Complexation behavior of SFX with Fe(II), both in solid and liquid phases has been studied by elemental analysis, IR.-spectra and polarographic and amperometric methods. SFX produces a single cathodic reduction wave in 0.1 M ammonium tartrate (supporting electrolyte) at pH 6.0 ±0.1. The wave is diffusion controlled and wave height is proportional to the concentration of SFX. The complex is also reversibly reduced at the electrode surface with diffusion-controlled kinetics. The stoichiometry of the Fe(II)- SFX complex is 1:1. Antibacterial studies on the drug and its metal complex have been performed against different bacteria. The observed results revealed the complex to be more potent in its antibacterial activity as compared to the parent drug. On the basis of observed results it could be concluded that the prepared Fe(II)- SFX complex may be recommended to the therapeutic experts for its possible use as a more potent antibiotic drug.