Table of Contents
Metal-Based Drugs
Volume 9 (2002), Issue 1-2, Pages 45-51
http://dx.doi.org/10.1155/MBD.2002.45

Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides

Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga LV-I006, Latvia

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.