Table of Contents
Metal-Based Drugs
Volume 8 (2002), Issue 6, Pages 307-313

Silacyclic Derivatives of Heteroaromatic Sulfides as Selective Cholesterol Level Lowering and Vasodilating Agents

Latvian Institute of Organic Synthesis, 21 Aizkraukles street, Riga LV-1006, Latvia

Received 9 January 2002; Accepted 15 January 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K2CO3 / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.