Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives

Abstract

O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me3 SnOSPR’R”(2), Ph3 SnOSPR’R”(3), O(CH2CH2S)2 Sn(n-Bu)OSPR’R”(4), S(CH2CH2S)2 Sn(n-Bu)OSPR’R”(5), (R’ = O-phenyl; R”= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines.