Table of Contents
Metal-Based Drugs
Volume 8, Issue 6, Pages 333-335
http://dx.doi.org/10.1155/MBD.2002.333

Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives

1Center of Chemical Research., Autonomous University of Morelos, Av. Universidad 1001, Cuernavaca 62210, Morelos, Mexico
2Institute of Chemistry, National Autonomous University of México, Circuito Exterior, Ciudad Universitaria, D.F.,México 04510, Mexico
3Center of Biotechnology Research., Autonomous University of Morelos., Mexico

Received 7 April 2002; Accepted 8 May 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me3 SnOSPR’R”(2), Ph3 SnOSPR’R”(3), O(CH2CH2S)2 Sn(n-Bu)OSPR’R”(4), S(CH2CH2S)2 Sn(n-Bu)OSPR’R”(5), (R’ = O-phenyl; R”= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines.