Table of Contents
Metal-Based Drugs
Volume 8, Issue 5, Pages 249-252
http://dx.doi.org/10.1155/MBD.2002.249

Apoptosis Induced by Metal Complexes and Interaction with Dexamethasone

1Institute of Biomedical Sciences of the University of São Paulo, Department of Pharmacology, Av. Prof. Lineu Prestes, 1524, São Paulo SP- 05508-900, Brazil
2Faculty of Medical Sciences of the Santa Casa de São Paulo, R. Da. Veridiana, 311 São Paulo, SP-01238-010, Brazil

Received 9 January 2002; Accepted 14 January 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Apoptosis induced by rhodium II amidate, rhodium II propionate, cisplatin and interactions with dexamethaxone were studied on some human leukemia cell lines Raji, Jurkat and U937. Apoptosis was studied by flow cytometry, agarose gel electrophoresis and morphological analysis. Rhodium II propionate induced apoptosis in all the three cell lines, Rhodium II amidate, in the lymphoid cell lines Jurkat and Raji, and cisplatin, only in the Jurkat, a T lymphoid cell line. It has also been observed that the addition of dexamethasone enhances the apoptosis index only in U937, a monocytic line with a glucocorticoid receptor bearing.