Aijaz Ahmad Tak, Farukh Arjmand, Sartaj Tabassum, "Synthesis of New Five Coordinated Copper(II) and Nickel(II) Complexes of L-Valine and Kinetic Study of Copper(II) with Calf Thymus DNA", Metal-Based Drugs, vol. 9, Article ID 681839, 10 pages, 2002. https://doi.org/10.1155/MBD.2002.81
Synthesis of New Five Coordinated Copper(II) and Nickel(II) Complexes of L-Valine and Kinetic Study of Copper(II) with Calf Thymus DNA
Five coordinated novel complexes of and have been synthesized from benzil and 1,3- diaminopropane-/ complex and characterized by elemental analysis, i.r., n.m.r., e.p.r, molar conductance and u.v-vis, spectroscopy. The complexes are ionic in nature and exhibit pentaeoordinated geometry around the metal ion. The reaction kinetics of with calf thymus DNA was studied by u.v-vis, spectroscopy in aqueous medium. The complex after interaction with calf thymus DNA shows shift in the absorption spectrum and hypochromicity indicating an intercalative binding mode. The values have been calculated under pseudo-first order conditions. The redox behaviour of complex in the presence and in the absence of calf thymus DNA in the aqueous solution has been investigated by cyclic voltammetry. The cyclic voitammogram exhibits one quasi-reversible redox wave corresponding to / redox couple with values of -0.377 and -0.237 V respectively at a scan rate of 0.1V .On interaction with calf thymus DNA, the complex exhibits shifts in both as well as in values, indicating strong binding of the complex to the calf thymus DNA.
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