Table of Contents
Metal-Based Drugs
Volume 8 (2002), Issue 5, Pages 275-281
http://dx.doi.org/10.1155/MBD.2002.275

Synthesis, Characterization and Biological Activity of Dimethyltin Dicarboxylates Containing Germanium

1Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad Muzaffarabad- 13100, Pakistan
2Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
3Department of Chemistry and Physics, University of the District of Columbia, WashingtoD.C., USA

Received 1 January 2002; Accepted 19 January 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of diorganotin dicarboxylates of the general formula (CH3)2Sn(OCOCHR3CHR2GeR1)2 where R1=(C6H5)3 , (P-CH3C6H4)3 , N(CH2CH2O)3 , R2=C6H5 , H, CH3 , P-CH3OC6H4 , P-ClC6H4 , P-CH3C6H4 , R3=CH3 and H, have been synthesized by the reaction of dimethyltin oxide with germanium substituted propionic acid in 1:2 molar ratio in toluene. The H2O formed was removed azeotropically using a Dean and Stark apparatus. All the compounds have been characterized by IR, multinuclear (H1 , C13 , S119n ) NMR, mass and Mössbauer spectroscopies. All compounds were found to have potential activity against bacteria.