Table of Contents
Metal-Based Drugs
Volume 8, Issue 6, Pages 337-345
http://dx.doi.org/10.1155/MBD.2002.337

Metal–5-Fluorouracil–Histamine Complexes: Solution, Structural, and Antitumour Studies

1Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India
2School of Biotechnology, Banaras Hindu University, Varanasi 221 005, India
3Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, Bochum D-44801, Germany

Received 15 May 2002; Accepted 29 May 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Solution studies were performed pH-metrically to study the interaction of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions with 5-fluorouracil (5FU) and histamine (Hm) separately (binary) and in the presence of each other (ternary) at 25±0.1C° temperature and a constant ionic strength of 0.1 M NaNO3 in aqueous solution. The ternary complexes have been found to be more stable than the corresponding binary complexes as shown by the positive value of ΔlogK. The species distribution curves have been obtained using the computer programme BEST. On the basis of species distribution results, efforts were also made to prepare some mixed complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) ions by performing the reaction of their metal nitrates, 5FU and Hm in aqueous ethanol medium at suitable pH. The isolated solid complexes were characterized by different physico-chemical method in order to suggest the possible binding site of the ligands and the structure of the resultant complexes. All these complexes were checked for their antitumour activity by injecting in Dalton's lymphoma (DL) and Sarcoma-180 (S-180) bearing C3H/He mice. The results indicate that some complexes have good antitumour activity both in vivo and in vitro.