Table of Contents
Metal-Based Drugs
Volume 8, Issue 5, Pages 269-274
http://dx.doi.org/10.1155/MBD.2002.269

Antibacterial and Antifungal Activity of Zinc(II) Carboxylates With/Without N-Donor Organic Ligands

1Department of Inorganic Chemistry, P. J. Safárik University, Moyzesova 11, Kosice 041 54, Slovakia
2Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 832 32, Slovakia

Received 11 September 2000; Accepted 23 January 2001

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antibacterial and antifungal activity of zinc(II) carboxylates with composition Zn(RCOO)2•nH2O(R =H-, CH3 , CH3CH2CH2- , (CH3)2CH- , XCH2- , X=Cl, Br, I, n=0 or 2), [ZnX2(Nia+CH2COO-)2] (Nia=nicotinamide, X=Cl, Br, I) and [Zn(XCH2COO)2(Caf)2]•2H2O (Car=caffeine, X=Cl, Br) is studied against bacterial strains Staphylococcus aureus, Escherichia coli and yeast Candida albicans. The structural types are assigned to the prepared compounds and the influence of (i) carboxylate chain length, (ii) substitution of hydrogen atom of carboxylate by halogen and (iii) presence of N-donor organic ligands on the biological activity is discussed.