Table of Contents
Metal-Based Drugs
Volume 8, Issue 6, Pages 303-306
http://dx.doi.org/10.1155/MBD.2002.303

Cytotoxicity of Triorganophosphinegold(I) n-Mercaptobenzoates, n = 2, 3 and 4

1Medical Department, Pharmachemie B.V., Haarlem NL-2003, The Netherlands
2Department of Chemistry, The Univeristy of Adelaide, 5005, Australia
3Department of Chemistry, National University of Singapore, Singapore 117543, Singapore

Received 2 April 2002; Accepted 10 April 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The results of cytotoxicity trials against a panel of seven human cell lines for a series of triorganophosphinegold(I) 3- and 4-mercaptobenzoates are reported. While the new compounds show moderate to high toxicity, their potencies are inferior to those reported previously for their isomeric 2- mercaptobenzoate derivatives. The results therefore suggest a structure-activity relationship in that the 2-isomeric species are more active, particularly against the non-small cell lung cancer and renal cancer cell lines, results that may indicate some selectivity in their cytotoxic profile.