Synthesis and Anchoring of Antineoplastic Ferrocene and Phthalocyanine Derivatives on Water-Soluble Polymeric Drug Carriers Derived from Lysine and Aspartic Acid

<table><i>Main
picture</i>:  Colour-coded general
synthetic strategy towards the syntheses of polymeric drug carrier
devices.   Right, in blue:  functionalisation of the antineoplastic drug,
ferrocene, to 3-ferrocenylbutanoic acid.  
Left:   The synthesis of a specific
ferrocene-containing drug delivery device derived from aspartic acid.   The colour codes in the side portions are
the same as those used in the central main picture.     The
main picture was reproduced with permission from copyright owner “International
Union of Pure and Applied Chemistry.” An adaption of the main part of this scheme
was previously published as follows: J. C. Swarts, in <i>Macromol. Sym</i>., Eds. K. Levon and A. Guiseppi-Elie), vol 186,
pages 123–128, 2002; Copyright Wiley-VCH Verlag GmbH &amp; Co. KgaA, reproduced with
permission.</table>

Metal-Based Drugs

sch1

Scheme 1

Scheme 1: Synthesis and Anchoring of Antineoplastic Ferrocene and Phthalocyanine Derivatives on Water-Soluble Polymeric Drug Carriers Derived from Lysine and Aspartic Acid 

Scheme 1 | Synthesis and Anchoring of Antineoplastic Ferrocene and Phthalocyanine Derivatives on Water-Soluble Polymeric Drug Carriers Derived from Lysine and Aspartic Acid 