Synthesis and Anchoring of Antineoplastic Ferrocene and Phthalocyanine Derivatives on Water-Soluble Polymeric Drug Carriers Derived from Lysine and Aspartic Acid

Scheme 2

Syntheses of polymeric drug carrying devices 11, 12 (M = Co), and 13. For PDT applications, M = Zn or Cl–Al would be more appropriate [18]. All polymers have a random recurring unit arrangement in the backbone. The indicated structures are meant to show building block ratios rather than block polymers. Opening of the succinimide rings of 6 with nucleophiles R¹-NH₂ lead to a mixture of and ring-opened aspartates. For convenience, only the -form is shown.