Synthesis, Structure, Electrochemistry, and Spectral Characterization of Bis-Isatin Thiocarbohydrazone Metal Complexes and Their Antitumor Activity Against Ehrlich Ascites Carcinoma in Swiss Albino Mice

Table 4

Effect of drugs on body weight changes in tumor-induced mice.

Group	Dose (mg/Kg) i.p.	% increase in weight as compared to Day-0 (mean ± SE)
		Day-3	Day-6	Day-9	Day-12	Day-15
Control	—	4.46±1.98	7.04±2.19	16.13±1.75	17.15±1.89	19.15±2.22
Cisplatin	3.5	4.51±1.15	12.04±1.38	19.16±1.34	9.91±2.12^a	1.32±4.23^a
[Cu(L)Cl]⋅2H2O	50	5.45±1.25	16.27±3.29	22.13±5.76	15.35±1.88	4.56±2.56^a
[Cu(L)OAc]⋅2H2O	50	5.55±1.83	14.19±2.37	21.09±2.42	15.24±2.65	6.36±2.55^a
Ligand	50	4.88±2.02	14.33±4.37	24.69±4.99	16.54±2.35	7.76±3.43^a

a𝑃<.05 versus Control.