Synthesis, Structure, Electrochemistry, and Spectral Characterization of Bis-Isatin Thiocarbohydrazone Metal Complexes and Their Antitumor Activity Against Ehrlich Ascites Carcinoma in Swiss Albino Mice

Table 6

Effect of drugs on the survival time in tumor-induced mice.

Group	Dose (mg/kg)	Median survival time (days)			Mean survival time (days)
		MST	%T/C	%ILS	(Mean ± SEM)	%T/C	%ILS
Control	—	18.00	—	—	18.33±0.21	—	—
Cisplatin	3.5	34.50	191.67	91.67	34.33±0.33^a	187.28	87.28
[Cu(L)Cl]⋅2H2O	50	26.00	144.44	44.44	26.17±0.31^a	142.77	42.77
[Cu(L)OAc]⋅2H2O	50	25.00	138.88	38.88	24.67±0.21^a	134.59	34.59
Ligand	50	23.00	127.77	27.77	23.00±0.37^a	125.48	25.48

a𝑃<.05 versus control groups, MST = Median Survival Time.