Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism

Table 1

Comparison of the cytotoxicity of cisplatin, LA-12 and satraplatin (JM-216) against cisplatin-resistant tumor cell lines. Values of IC₅₀ were calculated for 24 hour exposure time (adapted from Turánek et al. Anticancer Drugs. 2004,15:537-543).

Cancer cell line	IC50 (𝜇M )
	Cisplatin	LA-12	Satraplatin
K562	>80	3	63
KG-1	48	2	63
ML-2	>80	1	56
B16	>80	6	>80
HT-29N	>80	12	>80
HT-29	50	8	70
HCT116	>80	9	>80
A427	63	6	13
HBL100	63	6	>80
MCF-7	71	8	70
CPRL23/CTR	>80	25	56
A2780	7	4	63
A2780cis40	40	3	40
A2790cis90	>80	7	63