Table of Contents
Metal-Based Drugs
Volume 2008, Article ID 723634, 7 pages
Research Article

Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2-Bipyridyl

1Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
2Liver Research Laboratory, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt

Received 27 May 2007; Revised 30 October 2007; Accepted 13 February 2008

Academic Editor: Rafael Moreno-Sanchez

Copyright © 2008 Sahar I. Mostafa and Farid A. Badria. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synthesis of two new water-soluble mixed ligand [Pd(bpy)(dahmp)]Cl and [Ag(bpy)(Hdahmp)]NO3 complexes (dahmp and Hdahmp are the deprotonated monoanion and the protonated neutral 4,6-diamino-5-hydroxy-2-mercaptopyrimidine, resp.) is reported. The composition of the reported complexes was discussed on the bases of IR, H1 NMR, and mass spectra, as well as conductivity and thermal measurements. The reported complexes display a significant anticancer activity against Ehrlich ascites tumor cells (EACs). The higher activity of these complexes with their higher conductivity values corresponds to their complete ionization in aqueous solution.