Table of Contents
Metal-Based Drugs
Volume 2008, Article ID 864653, 5 pages
Research Article

The In Vitro Antitumour Activity of Novel, Mitochondrial-Interactive, Gold-Based Lipophilic Cations

1Department of Pharmacology, University of Pretoria, P.O. Box 2034, Pretoria 0001, South Africa
2School of Chemistry, University of the Witwatersrand, Private Bag 3, Johannesburg 2050, South Africa

Received 18 July 2007; Accepted 1 October 2007

Academic Editor: Jannie C Swarts

Copyright © 2008 Sherika Mahepal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. Berners-Price, C. K. Mirabelli, R. K. Johnson et al., “In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride,” Cancer Research, vol. 46, no. 11, 5486 pages, 1986. View at Google Scholar
  2. M. J. McKeage, S. J. Berners-Price, P. Galettis et al., “Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes,” Cancer Chemotherapy and Pharmacology, vol. 46, no. 5, 343 pages, 2000. View at Publisher · View at Google Scholar
  3. R. J. Bowen, A. C. Garner, S. J. Berners-Price, I. D. Jenkins, and R. E. Sue, “Convenient synthetic routes to bidentate and monodentate 2-, 3- and 4-pyridyl phosphines: potentially useful ligands for water-soluble complex catalysts,” Journal of Organometallic Chemistry, vol. 554, no. 2, 181 pages, 1998. View at Publisher · View at Google Scholar
  4. M. J. McKeage, L. Maharaj, and S. J. Berners-Price, “Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes: the possible role of mitochondria,” Coordination Chemistry Reviews, vol. 232, no. 1-2, 127 pages, 2002. View at Publisher · View at Google Scholar
  5. P. F. Smith, G. D. Hoke, D. W. Alberts et al., “Mechanism of toxicity of an experimental bidentate phosphine gold complexed antineoplastic agent in isolated rat hepatocytes,” Journal of Pharmacology and Experimental Therapeutics, vol. 249, no. 3, 944 pages, 1989. View at Google Scholar
  6. V. R. Fantin, M. J. Berardi, L. Scorrano, S. J. Korsmeyer, and P. Leder, “A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth,” Cancer Cell, vol. 2, no. 1, 29 pages, 2002. View at Publisher · View at Google Scholar
  7. P. Bernardi, L. Scorrano, R. Colonna, V. Petronilli, and F. Di Lisa, “Mitochondria and cell death. Mechanistic aspects and methodological issues,” European Journal of Biochemistry, vol. 264, no. 3, 687 pages, 1999. View at Publisher · View at Google Scholar
  8. J. S. Modica-Napolitano and J. R. Aprille, “Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells,” Advanced Drug Delivery Reviews, vol. 49, no. 1-2, 63 pages, 2001. View at Publisher · View at Google Scholar
  9. S. Davis, M. J. Weiss, J. R. Wong, T. J. Lampidis, and L. B. Chen, “Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells,” Journal of Biological Chemistry, vol. 260, no. 25, 13844 pages, 1985. View at Google Scholar
  10. S. J. Berners-Price, R. J. Bowen, P. Galettis, P. C. Healy, and M. J. McKeage, “Structural and solution chemistry of gold(I) and silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agents,” Coordination Chemistry Reviews, vol. 185-186, 823 pages, 1999. View at Publisher · View at Google Scholar
  11. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, 55 pages, 1983. View at Publisher · View at Google Scholar
  12. C. E. J. van Rensburg, R. Anderson, M. S. Myer, G. K. Joone, and J. F. O'Sullivan, “The riminophenazine agents clofazimine and B669 reverse acquired multidrug resistance in a human lung cancer cell line,” Cancer Letters, vol. 85, no. 1, 59 pages, 1994. View at Publisher · View at Google Scholar
  13. S. J. Berners-Price, R. J. Bowen, M. A. Fernandes et al., “Gold(I) and silver(I) complexes of 2,3-bis(diphenylphosphino)maleic acid: structural studies and antitumour activity,” Inorganica Chimica Acta, vol. 358, no. 14, 4237 pages, 2005. View at Publisher · View at Google Scholar