In Vitro Evaluation of Oxoplatin: An Oral Platinum(IV) Anticancer Agent

Table 1

Selected genes exhibiting > fourfold upregulated expression in H526 cells that were treated with oxoplatin assorted according to their cellular function. H526 SCLC cells were either left untreated or treated with 3.75 𝜇M oxoplatin, respectively, in tissue culture flasks for three days. Thereafter, RNA of control and treated cells was extracted, and gene expression was analyzed using the Applied Biosystems Human Genome Survey Microarray V2.0.

Cellular process	Locus link	Gene symbol	Gene name
Transcription	2306	FOXD2	Forkhead box D2
	5450	POU2AF1	POU domain, class 2, associating factor 1
	1649	DDIT3	DNA-damage-inducible transcript 3
Apoptosis	84301	DDI2	DNA-damage inducible protein 2
	9518	GDF15	Growth differentiation factor 15
	836	CASP3	Caspase 3, apoptosis-related cysteine protease
	8349	HIST2H2BE	Histone 2, H2be
Cytoskeleton	649	BMP1	Bone morphogenetic protein 1
	2620	GAS2	Growth arrest-specific 2
	5414	PNUTL2	Peanut-like 2 (Drosophila)
	5100	PCDH8	Protocadherin 8
Signal transduction	10673	TNFSF13B	Tumor necrosis factor (ligand) superfamily, member 13b
	10368	CACNG3	Calcium channel, voltage-dependent, gamma subunit 3
	8416	ANXA9	Annexin A9
	1184	CLCN5	Chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease)
	147798	TMC4	Transmembrane channel-like 4
Metabolism	50506	DUOX2	Dual oxidase 2
	81894	SLC25A28	Solute carrier family 25, member 28
	3067	HDC	Histidine decarboxylase
	8644	AKR1C3	Aldo-keto reductase family 1, member C3
	6569	SLC34A1	Solute carrier family 34 (sodium phosphate), member 1
	10404	PGCP	Plasma glutamate carboxypeptidase
	9709	HERPUD1	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
	6303	SAT	Spermidine/spermine N1-acetyltransferase
Transport	1520	CTSS	Cathepsin S
	27074	LAMP3	Lysosomal-associated membrane protein 3
	4189	DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9