Table of Contents
Metal-Based Drugs
Volume 2009, Article ID 681270, 9 pages
http://dx.doi.org/10.1155/2009/681270
Research Article

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion

1Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy
2Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria
3Department of Life Sciences, University of Trieste, Via L. Giorgieri 7, 34127 Trieste, Italy

Received 16 April 2009; Accepted 22 June 2009

Academic Editor: Simon Fricker

Copyright © 2009 A. Bergamo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effects of indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019, or FFC14A), the second ruthenium compound that entered clinical trials, in an in vitro model of tumour invasion and metastasis show that the antitumour effects of this compound might include also the modulation of cell behaviour although its cytotoxicity appears to be predominant over these effects. The comparison with its imidazole analogue KP418 shows however its superiority, being able to control in vitro cell growth and in some instances also in vivo tumour development. These results suggest that the activity of KP1019 is predominantly due to direct cytotoxic effects for tumour cells, evident also in vivo on primary tumour growth and that the effects on modulation of the biological behaviour of the cancer cell can be present but might have only a partial role.