Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion
Effect of KP418 and KP1019 on migration of cells through polycarbonate filters. MDA-MB-231, MCF-7, and HBL-100 cells were treated for 1 hour with KP418, KP1019 M, and KP1019# (# is equal to M for MDA-MB-231 and MCF-7 and to M for HBL-100), then the cells were removed from the flasks, collected, resuspended, and seeded on the inserts of Transwell cell culture chambers. Data represent cells that after 24 hours have migrated and are present on the lower surface of the filter. Data are the percent of variation versus controls calculated from the mean S.D. of two experiments each performed in triplicate, : : ; : versus controls, ANOVA, and Tukey-Kramer post test.
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