Metal-Based Drugs

Metal-Based Drugs / 2009 / Article / Tab 1

Research Article

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion

Table 1

Effect of KP418 and KP1019 on cell viability.

MDA-MB-231MCF-7HBL-100

Controls2.284 0.0662.631 0.0552.308 0.424
KP418 (  M )1.832 = 0.04 2.763 0.0402.269 0.159
(79.9%)(105%)(97.0%)

MDA-MB-231MCF-7HBL-100
Controls1.482 0.0161.178 0.0730.999 0.055
KP1019 (  M)1.435 0.0401.184 0.0511.076 0.055
(96.8%)(101%)(107%)
KP1019 (  M)1.361 0.05 1.04 0.03 0.901 0.081
(91.8%)(88.3%)(90.2%)
KP1019 (  M)0.847 0.02 0.862 0.09 0.328 0.05
(57.2%)(73.2%)(32.9%)

MDA-MB-231, MCF-7, and HBL-100 cells were treated for 1 hour with KP418  M and KP1019  M, then the cells were removed from the flasks, collected, resuspended in culture medium and seeded on 96 well plates. After 24 hours cell viability was determined by the MTT assay. Data are the mean optical density S.D. of two experiments each performed in quadruplicate. Data in parentheses represent the percentage of each treated group versus the relevant controls (T/C%), : , : versus controls, ANOVA, and Tukey-Kramer post test.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.