Table of Contents
Molecular Biology International
Volume 2010 (2010), Article ID 573426, 6 pages
http://dx.doi.org/10.4061/2010/573426
Research Article

Interferon Alpha Characterization and Its Comparative Expression in PBM Cells of Capra hircus and Antelope cervicapra Cultured in the Presence of TLR9 Agonist

1Centre for Wildlife, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122, India
2Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122, India

Received 11 January 2010; Accepted 28 March 2010

Academic Editor: Yogesh C. Awasthi

Copyright © 2010 Ramesh Doreswamy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. Noppert, K. A. Fitzgerald, and P. J. Hertzog, “The role of type I interferons in TLR responses,” Immunology and Cell Biology, vol. 85, no. 6, pp. 446–457, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Guzylack-Piriou, C. Balmelli, K. C. Mccullough, and A. Summerfield, “Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete interferon-α, tumour necrosis factor-α and interleukin-12,” Immunology, vol. 112, no. 1, pp. 28–37, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Hochrein, B. Schlatter, M. O'Keeffe et al., “Herpes simplex virus type-1 induces IFN-a production via Toll-like receptor 9-dependent and -independent pathways,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 31, pp. 11416–11421, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Krug, S. Rothenfusser, V. Hornung et al., “Identification of CpG oligonucleotide sequences with high induction of IFN-a/ß in plasmacytoid dendritic cells,” European Journal of Immunology, vol. 31, no. 7, pp. 2154–2163, 2001. View at Google Scholar · View at Scopus
  5. F. H. A. Fakher, N. Rachinel, M. Klimczak, J. Louis, and N. Doyen, “TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors TH1 cell development and the resolution of lesions,” Journal of Immunology, vol. 182, no. 3, pp. 1386–1396, 2009. View at Google Scholar · View at Scopus
  6. D. C. Bartholomeu, C. Ropert, M. B. Melo et al., “Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi,” Journal of Immunology, vol. 181, no. 2, pp. 1333–1344, 2008. View at Google Scholar · View at Scopus
  7. A. E. Seif, D. M. Barrett, M. Milone, V. I. Brown, S. A. Grupp, and G. S. D. Reid, “Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses,” Blood, vol. 114, no. 12, pp. 2459–2466, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Christopher and J. P. Wong, “Broad-spectrum drugs against viral agents,” International Journal of Molecular Sciences, vol. 9, no. 9, pp. 1561–1594, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Zimmermann, A. Dalpke, and K. Heeg, “CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections,” International Journal of Medical Microbiology, vol. 298, no. 1-2, pp. 39–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. D. K. Das, M. Saini, A. Dhara, D. Swarup, S. Kumar, and P. K. Gupta, “Molecular characterization of toll-like receptor 2 of ruminants and comparative expression in nilgai (Boselaphus tragocamelus) vs. buffalo (Bubalus bubalis),” International Journal of Immunogenetics, vol. 35, no. 3, pp. 227–234, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Dhara, M. Saini, D. K. Das et al., “Molecular characterization of coding sequences and analysis of Toll-like receptor 3 mRNA expression in water buffalo (Bubalus bubalis) and nilgai (Boselaphus tragocamelus),” Immunogenetics, vol. 59, no. 1, pp. 69–76, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. P. E. Baker and K. F. Knoblock, “Bovine costimulator. II. Generation and maintenance of a bovine costimulator-dependent bovine lymphoblastoid cell line,” Veterinary Immunology and Immunopathology, vol. 2, pp. 467–469, 1982. View at Google Scholar
  13. K. Tamura, J. Dudley, M. Nei, and S. Kumar, “MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0,” Molecular Biology and Evolution, vol. 24, no. 8, pp. 1596–1599, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Menzies and A. Ingham, “Identification and expression of Toll-like receptors 1–10 in selected bovine and ovine tissues,” Veterinary Immunology and Immunopathology, vol. 109, no. 1-2, pp. 23–30, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. W. Pfaffl, “A new mathematical model for relative quantification in real-time RT-PCR,” Nucleic Acids Research, vol. 29, no. 9, p. e45, 2001. View at Google Scholar
  16. M. Spinu, O. Spinu, and A. A. Degen, “Haematological and immunological variables in a domesticated and wild subspecies of ostrich (Struthio camelus),” British Poultry Science, vol. 40, no. 5, pp. 613–618, 1999. View at Google Scholar · View at Scopus
  17. J. K. Gaydos, W. R. Davidson, F. Elvinger, D. G. Mead, E. W. Howerth, and D. E. Stallknecht, “Innate resistance to epizootic hemorrhagic disease in white-tailed deer,” Journal of Wildlife Diseases, vol. 38, no. 4, pp. 713–719, 2002. View at Google Scholar · View at Scopus
  18. A. R. Gupta, R. C. Patra, M. Saini, and D. Swarup, “Haematology and serum biochemistry of chital (Axis axis) and barking deer (Muntiacus muntjak) reared in semi-captivity,” Veterinary Research Communications, vol. 31, no. 7, pp. 801–808, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Isaacs and J. Lindenmann, “Virus interference. I. The interferon,” Proceedings of Royal Society London Series B, vol. 147, no. 927, pp. 258–267, 1957. View at Google Scholar
  20. R. M. Lawn, J. Adelman, and T. J. Dull, “DNA sequence of two closely linked human leukocyte interferon genes,” Science, vol. 212, no. 4499, pp. 1159–1162, 1981. View at Google Scholar · View at Scopus
  21. V. Van Pesch, H. Lanaya, J.-C. Renauld, and T. Michiels, “Characterization of the murine alpha interferon gene family,” Journal of Virology, vol. 78, no. 15, pp. 8219–8228, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. U. Schultz, J. Kock, H.-J. Schlicht, and P. Staeheli, “Recombinant duck interferon: a new reagent for studying the mode of interferon action against hepatitis B virus,” Virology, vol. 212, no. 2, pp. 641–649, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. M. J. Sekellick, A. F. Ferrandino, D. A. Hopkins, and P. I. Marcus, “Chicken interferon gene: cloning, expression, and analysis,” Journal of Interferon Research, vol. 14, no. 2, pp. 71–79, 1994. View at Google Scholar · View at Scopus
  24. M. Suresh, K. Karaca, D. Foster, and J. M. Sharma, “Molecular and functional characterization of turkey interferon,” Journal of Virology, vol. 69, no. 12, pp. 8159–8163, 1995. View at Google Scholar · View at Scopus
  25. B. Robertsen, “The interferon system of teleost fish,” Fish and Shellfish Immunology, vol. 20, no. 2, pp. 172–191, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Omatsu, E.-J. Bak, Y. Ishii et al., “Induction and sequencing of Rousette bat interferon a and ß genes,” Veterinary Immunology and Immunopathology, vol. 124, no. 1-2, pp. 169–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. R. M. Roberts, L. Liu, and A. Alexenko, “New and atypical families of type I interferons in mammals: comparative functions, structures, and evolutionary relationships,” Progress in Nucleic Acid Research and Molecular Biology, vol. 56, pp. 287–325, 1997. View at Google Scholar · View at Scopus
  28. G. Cheng, W. Chen, Z. Li et al., “Characterization of the porcine alpha interferon multigene family,” Gene, vol. 382, pp. 28–38, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. C. P. A. Ivory, M. Prystajecky, C. Jobin, and K. Chadee, “Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA,” Infection and Immunity, vol. 76, no. 1, pp. 289–297, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Wonderling, T. Powell, S. Baldwin et al., “Cloning, expression, purification, and biological activity of five feline type I interferons,” Veterinary Immunology and Immunopathology, vol. 89, no. 1-2, pp. 13–27, 2002. View at Publisher · View at Google Scholar · View at Scopus