Glycolysis in the African Trypanosome: Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development

Figure 1

Glycolysis and glycosomes in the bloodstream form African trypanosome. Abbreviations: ALD: aldolase; DHAP: dihydroxyacetone phosphate; 1,3BPGA: 1,3-bisphosphoglycerate; ENO: enolase; F-6-P: fructose-6-phosphate; FBP: fructose 1,6-bisphosphate; G-3-P: glyceraldehyde 3-phosphate; G-6-P: glucose-6-phosphate; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; Glc: glucose; Gly-3-p: glycerol-3-phosphate; GPDH: glycerol 3-phosphate dehydrogenase; Mito: mitochondrial enzymes; PEP: phosphoenolpyruvate; 2-PGA: 2-phosphoglycerate; 3-PGA: 3-phosphoglycerate; PGI: glucose-6-phosphate isomerase; PGM: phosphoglycerate mutase; PFK: phosphofructokinase; PGK: phosphoglycerate kinase; PK: pyruvate kinase; PYR: pyruvate; TbHK: T. brucei hexokinase 1 and/or 2; TPI: triose-phosphate isomerase.