Bioinformatic Analysis of Leishmania donovani Long-Chain Fatty Acid-CoA Ligase as a Novel Drug Target
Figure 3
Amino acid sequence alignments of long-chain fatty acyl-CoA synthetases. The amino acid sequence of Leishmania LCFA (LdLCFA) was aligned with LC-FACS from T. thermophilus (ttLC-FACS, Q6L8FO), human (LCFA_HUMAN, P41215), yeast (LCF1_YEAST, P30624), and E. coli (LCFA_ECOLI, P29212). The boxed areas denoted with bold letters correspond to conserved motifs of long-chain fatty acyl-CoA ligase: G, A, and L motifs as well as the P-loop. Filled squares, open circles, filled circles, and filled triangles indicate residues believed to be involved in dimer formation, fatty acid binding, magnesium ion binding, and adenylate binding, respectively.
