Molecular Biology International / 2011 / Article / Tab 2 / Review Article
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones Table 2 Modulated proteins in naphthoimidazoles-treated epimastigotesa .
Protein description Expression status Treatment Trypanothione synthetase upregulated N1, N2, N3 Mitochondrial heat shock downregulated N1 Heat shock protein 60 downregulated N2 Elogation factor 1-
downregulated N1 Enolase 1 upregulated N3 Glutamamyl carboxypeptidase downregulated N1 Heat shock protein 85 upregulated/downregulated N1, N2, N3 Tyrosine aminotransferase downregulated N3 Cytochrome C oxidase subunit IV downregulated N2 Activated PKC receptor downregulated N3 Hypothetical protein downregulated N2 β -tubulindownregulated N1, N2 Pyruvate dehydrogenase E1 β subunit downregulated N3 Sterol 24-C-methyltransferases downregulated N2, N3 Elongation factor 1-β downregulated N2 Proteosome α 7 subunit downregulated N1 Peroxiredoxin downregulated N2 Hypothetical protein downregulated N1 IgE-dependent histamine-releasing factor downregulated N3 Elongation factor 2 downregulated N2 Dehydrogenase downregulated N3 Cystathionine β -synthase 6 downregulated N2 α -tubulindownregulated N3
a Reference [128 ].
