Nucleotide Excision Repair in Caenorhabditis elegans

Table 2

Nucleotide excision repair genes in C. elegans.

Mammalian gene		C. elegans gene	Available alleles	Sensitivity to UV	Additional affected processes	References
CETN2		R08D7.5?	tm3611
DDB1		ddb-1	tm1769		Development, protein turnover	[75]
ERCC1		ercc-1	tm1943
			tm1981
			tm2073	yes		[71]
ERCC4 (XPF)		xpf-1	e1487	yes	Meiosis	[71, 76–79]
			tm2842	yes*
			ok3039	no*
ERCC5 (XPG)		xpg-1	tm1670	yes	Apoptosis	[71, 73]
			tm1682	yes	Apoptosis	[71, 73]
ERCC6 (CSB)		csb-1	ok2335	yes		[71]
LIG1		lig-1	RNAi		Growth, development
LIG3		K07C5.3
PCNA		pcn-1	ok1905		Growth, development
			tm3157
			tm3241		Growth, development
POLD1		F10C2.4			embryogenesis	[80, 81]
POLH		polh-1	RNAi		DNA repair	[64, 79, 82]
POLK		polk-1	RNAi		Growth, embryogenesis, DNA repair	[79–81]
RAD23B		rad-23	ok1910
			tm2595	yes		[71]
			tm3690
RFC	RFC1	rfc-1	RNAi		Mutator, embryogenesis	[81, 83]
	RFC2	rfc-2	RNAi		Embryogenesis	[81]
	RFC3	rfc-3	RNAi		Mutator, embryogenesis	[81, 83]
	RFC4	rfc-4	RNAi		Growth, development	[80, 81]
	RFC5	F44B9.8	RNAI		Embryogenesis
RPA	RPA1	rpa-1	RNAi		Embryogenesis	[80]
	RPA2	rpa-2	ok1627		Growth, development
TFIIH	CCNH	cyh-3	RNAi		Growth, development	[80]
	CDK7	cdk-7	ax224		Transcription, cell cycle	[84]
	GTF2H1	R02D3.3	RNAi		Growth, development	[80]
	GTF2H2	T16H12.4	tm1767
			tm4960
	GTF2H3	Zk1128.4	ok1200		Growth, development
			tm1501		Growth, development
	GTF2H4	Y73F8A.24	RNAi		Embryogenesis	[81]
	GTF2H5	Y55B1AL.2
	MNAT1	mnat-1	tm2959		Development
	ERCC3 (XPB)	Y66D12A.15	RNAi		Apoptosis, embryogenesis	[73, 81, 85]
	ERCC2 (XPD)	Y50D7A.2			Apoptosis, embryogenesis	[73, 81, 85]
XPA		xpa-1	mn157	yes		[55, 63]
			ok698	yes	Apoptosis, lifespan?	[63, 65, 71, 86, 87]
			gk674
XPC		xpc-1	ok734	no*	Apoptosis	[72]
			tm3886	yes	Apoptosis	[71, 72]

Some phenotypes were taken from http://www.wormbase.org/ (WS221). For those genes for which no alleles are known, results from RNAi experiments are indicated.
*Represent unpublished results.