Copper and Its Complexes in Medicine: A Biochemical Approach

Table 2

Coordination modes of organic ligands in ternary Cu(II) complexes.

Ligands	Coordination mode of ligand L	Type of complex	Biological activity	Reference
L: acetylacetoneL^’: phenanthroline		[LCuL′]^+	Anticancer	[70]
L: glycineL^’: phenanthroline		[LCuL^’]^+	Anticancer	[70]
L: o-iodohippuric acidL^’: phenanthroline		[LCuL^’2]^+	Anticancer	[71]
L: Schiff base of diethylenetriamineL^’: 2-amino-2-thiazoline		LCuL^’Cl2	Anticancer, antibacterial, anti-inflammatory	[72]
L: oxolinic acidL^’: phenanthroline		LCuL^’Cl	Antibacterial	[73]
L: propyl-norfloxacinL^’: 2,2^’-bipyridineor phenanthroline		LCuL^’Cl	Antibacterial, DNA intercalator, anticancer, nuclease mimetic.	[74, 75]
L: sparfloxacinL^’: 2,2^’-bipyridine		LCuL^’Cl	Antibacterial, DNA intercalator, anticancer.	[76]
L: pefloxacinL’: 2,2^’-bipyridyl-amine	R = C2H5-, X= H, Y= H,	LCuL^’Cl	Antibacterial, DNA intercalator, SOD mimetic.	[55]
L: gatifloxacinL^’: phenanthroline or 2,2^’-bipyridylamine		LCuL^’Cl	Antibacterial, DNA intercalator, SOD mimetic	[55]
L: N,N^’-bis(4-methylphenyl) sulfonyl ethylenediamineL^’: phenanthroline		LCuL^’2	Nuclease mimetic	[77]