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Molecular Biology International
Volume 2011 (2011), Article ID 839872, 8 pages
The Role of miRNAs as Key Regulators in the Neoplastic Microenvironment
1Biological, Chemical and Physical Sciences Department, College of Arts and Sciences, Roosevelt University, Chicago, IL 60605, USA
2Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Received 21 December 2010; Accepted 6 February 2011
Academic Editor: Alessandro Desideri
Copyright © 2011 K. K. Wentz-Hunter and J. A. Potashkin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000.
- S. S. McAllister and R. A. Weinberg, “Tumor-host interactions: a far-reaching relationship,” Journal of Clinical Oncology, vol. 28, no. 26, pp. 4022–4028, 2010.
- A. J. Giaccia and E. Schipani, “Role of carcinoma-associated fibroblasts and hypoxia in tumor progression,” Current Topics in Microbiology and Immunology, vol. 345, pp. 31–45, 2010.
- R. M. Bremnes, T. Dønnem, S. Al-Saad et al., “The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer,” Journal of Thoracic Oncology, vol. 6, no. 1, pp. 209–217, 2011.
- F. Moinfar, Y. G. Man, G. L. Bratthauer, M. Ratschek, and F. A. Tavassoli, “Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type (“clinging ductal carcinoma in situ”): a simulator of normal mammary epithelium,” Cancer, vol. 88, no. 9, pp. 2072–2081, 2000.
- K. Kurose, K. Gilley, S. Matsumoto, P. H. Watson, X. P. Zhou, and C. Eng, “Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas,” Nature Genetics, vol. 32, no. 3, pp. 355–357, 2002.
- K. Fukino, L. Shen, S. Matsumoto, C. D. Morrison, G. L. Mutter, and C. Eng, “Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets,” Cancer Research, vol. 64, no. 20, pp. 7231–7236, 2004.
- R. Hill, Y. Song, R. D. Cardiff, and T. Van Dyke, “Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis,” Cell, vol. 123, no. 6, pp. 1001–1011, 2005.
- M. Allinen, R. Beroukhim, LI. Cai et al., “Molecular characterization of the tumor microenvironment in breast cancer,” Cancer Cell, vol. 6, no. 1, pp. 17–32, 2004.
- W. Qiu, M. Hu, A. Sridhar et al., “No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas,” Nature Genetics, vol. 40, no. 5, pp. 650–655, 2008.
- A. Enkelmann, J. Heinzelmann, F. von Eggeling, et al., “Specific protein and miRNA patterns characterise tumour-associated fibroblasts in bladder cancer,” Journal of Cancer Research and Clinical Oncology. In press.
- T. Schepeler, J. T. Reinert, M. S. Ostenfeld et al., “Diagnostic and prognostic microRNAs in stage II colon cancer,” Cancer Research, vol. 68, no. 15, pp. 6416–6424, 2008.
- K. H. Lee, C. Lotterman, C. Karikari et al., “Epigenetic silencing of microRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer,” Pancreatology, vol. 9, no. 3, pp. 293–301, 2009.
- D. G. Schaar, D. J. Medina, D. F. Moore, R. K. Strair, and YI. Ting, “miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation,” Experimental Hematology, vol. 37, no. 2, pp. 245–255, 2009.
- T. Ichimi, H. Enokida, Y. Okuno et al., “Identification of novel microRNA targets based on microRNA signatures in bladder cancer,” International Journal of Cancer, vol. 125, no. 2, pp. 345–352, 2009.
- T. Chiyomaru, H. Enokida, S. Tatarano et al., “MiR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer,” British Journal of Cancer, vol. 102, no. 5, pp. 883–891, 2010.
- M. S. Ostenfeld, J. B. Bramsen, P. Lamy et al., “MiR-145 induces caspase-dependent and-independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors,” Oncogene, vol. 29, no. 7, pp. 1073–1084, 2010.
- O. Aprelikova, X. Yu, J. Palla et al., “The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts,” Cell Cycle, vol. 9, no. 21, pp. 4387–4398, 2010.
- E. Bandrés, E. Cubedo, X. Agirre et al., “Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues,” Molecular Cancer, vol. 5, article 29, 2006.
- O. Slaby, M. Svoboda, P. Fabian et al., “Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer,” Oncology, vol. 72, no. 5-6, pp. 397–402, 2008.
- K. Motoyama, H. Inoube, Y. Takatsuno et al., “Over- and under-expressed microRNAs in human colorectal cancer,” International Journal of Oncology, vol. 34, no. 4, pp. 1069–1075, 2009.
- C. J. Wang, Z. G. Zhou, L. Wang et al., “Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer,” Disease Markers, vol. 26, no. 1, pp. 27–34, 2009.
- T. S. Wong, X. B. Liu, B. Y. H. Wong, R. W. M. Ng, A. P. W. Yuen, and W. I. Wei, “Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue,” Clinical Cancer Research, vol. 14, no. 9, pp. 2588–2592, 2008.
- LI. X. Yan, X. F. Huang, Q. Shao et al., “MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis,” RNA, vol. 14, no. 11, pp. 2348–2360, 2008.
- S. Valastyan, F. Reinhardt, N. Benaich et al., “A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis,” Cell, vol. 137, no. 6, pp. 1032–1046, 2009.
- J. Guo, Y. Miao, B. Xiao et al., “Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues,” Journal of Gastroenterology and Hepatology, vol. 24, no. 4, pp. 652–657, 2009.
- S. Veerla, D. Lindgren, A. Kvist et al., “MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31,” International Journal of Cancer, vol. 124, no. 9, pp. 2236–2242, 2009.
- V. Benes and M. Castoldi, “Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available,” Methods, vol. 50, no. 4, pp. 244–249, 2010.
- B. D'haene, J. O. Vandesompele, and J. Hellemans, “Accurate and objective copy number profiling using real-time quantitative PCR,” Methods, vol. 50, no. 4, pp. 262–270, 2010.
- Z. Yu, N. E. Willmarth, J. Zhou et al., “microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 18, pp. 8231–8236, 2010.
- T. A. Hembrough, K. R. Kralovich, L. Li, and S. L. Gonias, “Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation,” Biochemical Journal, vol. 317, no. 3, pp. 763–769, 1996.
- M. Wygrecka, L. M. Marsh, R. E. Morty et al., “Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung,” Blood, vol. 113, no. 22, pp. 5588–5598, 2009.
- K. Dass, A. Ahmad, A. S. Azmi, S. H. Sarkar, and F. H. Sarkar, “Evolving role of uPA/uPAR system in human cancers,” Cancer Treatment Reviews, vol. 34, no. 2, pp. 122–136, 2008.
- A. L. Harris, “Hypoxia—a key regulatory factor in tumour growth,” Nature Reviews Cancer, vol. 2, no. 1, pp. 38–47, 2002.
- B. Qian, D. Katsaros, L. Lu et al., “High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1,” Breast Cancer Research and Treatment, vol. 117, no. 1, pp. 131–140, 2009.
- F. M. Selaru, A. V. Olaru, T. Kan et al., “MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3,” Hepatology, vol. 49, no. 5, pp. 1595–1601, 2009.
- B. Song, C. Wang, J. Liu et al., “MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression,” Journal of Experimental and Clinical Cancer Research, vol. 29, no. 1, article 29, 2010.
- G. Gabriely, T. Wurdinger, S. Kesari et al., “MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators,” Molecular and Cellular Biology, vol. 28, no. 17, pp. 5369–5380, 2008.
- H. Xia, Y. Qi, S. S. Ng et al., “microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs,” Brain Research, vol. 1269, no. C, pp. 158–165, 2009.
- S. Sengupta, J. A. Den Boon, I. H. Chen et al., “MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 15, pp. 5874–5878, 2008.
- S. Ramaswamy, K. N. Ross, E. S. Lander, and T. R. Golub, “A molecular signature of metastasis in primary solid tumors,” Nature Genetics, vol. 33, no. 1, pp. 49–54, 2003.
- R. Kulshreshtha, M. Ferracin, S. E. Wojcik et al., “A microRNA signature of hypoxia,” Molecular and Cellular Biology, vol. 27, no. 5, pp. 1859–1867, 2007.
- Z. Hua, Q. Lv, W. Ye et al., “Mirna-directed regulation of VEGF and other angiogenic under hypoxia,” PLoS ONE, vol. 1, no. 1, article e116, 2006.
- C. Hebert, K. Norris, M. A. Scheper, N. Nikitakis, and J. J. Sauk, “High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma,” Molecular Cancer, vol. 6, article 5, 2007.
- R. B. Donker, J. F. Mouillet, D. M. Nelson, and Y. Sadovsky, “The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts,” Molecular Human Reproduction, vol. 13, no. 4, pp. 273–279, 2007.
- R. Kulshreshtha, M. Ferracin, M. Negrini, G. A. Calin, R. V. Davuluri, and M. Ivan, “Regulation of microRNA expression: the hypoxic component,” Cell Cycle, vol. 6, no. 12, pp. 1426–1431, 2007.
- L. Oliver, C. Olivier, F. B. Marhuenda, M. Campone, and F. M. Vallette, “Hypoxia and the malignant glioma microenvironment: regulation and implications for therapy,” Current Molecular Pharmacology, vol. 2, no. 3, pp. 263–284, 2009.
- B. Kaur, F. W. Khwaja, E. A. Severson, S. L. Matheny, D. J. Brat, and E. G. Van Meir, “Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis,” Neuro-Oncology, vol. 7, no. 2, pp. 134–153, 2005.
- J. A. Chan, A. M. Krichevsky, and K. S. Kosik, “MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells,” Cancer Research, vol. 65, no. 14, pp. 6029–6033, 2005.
- M. Yamakuchi, C. D. Lotterman, C. Bao et al., “P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 14, pp. 6334–6339, 2010.
- S. Cascio, A. D'Andrea, R. Ferla et al., “miR-20b modulates VEGF expression by targeting HIF-1α and STAT3 in MCF-7 breast cancer cells,” Journal of Cellular Physiology, vol. 224, no. 1, pp. 242–249, 2010.
- Z. Lei, BO. Li, Z. Yang et al., “Regulation of HIF-1α and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration,” PLoS ONE, vol. 4, no. 10, Article ID e7629, 2009.
- L. K. Mathew and M. C. Simon, “mir-210: a sensor for hypoxic stress during tumorigenesis,” Molecular Cell, vol. 35, no. 6, pp. 737–738, 2009.
- M. E. Crosby, R. Kulshreshtha, M. Ivan, and P. M. Glazer, “MicroRNA regulation of DNA repair gene expression in hypoxic stress,” Cancer Research, vol. 69, no. 3, pp. 1221–1229, 2009.
- M.-P. Puisségur, N. M. Mazure, T. Bertero et al., “MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity,” Cell Death and Differentiation, vol. 18, no. 3, pp. 465–478, 2011.
- Z. Chen, Y. Li, H. Zhang, P. Huang, and R. Luthra, “Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression,” Oncogene, vol. 29, pp. 4362–4368, 2010.
- X. Huang, L. Ding, K. L. Bennewith et al., “Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation,” Molecular Cell, vol. 35, no. 6, pp. 856–867, 2009.
- A. S. Ho, X. Huang, H. Cao et al., “Circulating miR-210 as a novel hypoxia marker in pancreatic cancer,” Translational Oncology, vol. 3, no. 2, pp. 109–113, 2010.
- H. E. Gee, C. Camps, F. M. Buffa et al., “hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer,” Cancer, vol. 116, no. 9, pp. 2148–2158, 2010.
- C. S. Neal, M. Z. Michael, L. H. Rawlings, M. B. Van der Hoek, and J. M. Gleadle, “The VHL-dependent regulation of microRNAs in renal cancer,” BMC Medicine, vol. 8, article 64, 2010.
- J. D. Gordan and M. C. Simon, “Hypoxia-inducible factors: central regulators of the tumor phenotype,” Current Opinion in Genetics and Development, vol. 17, no. 1, pp. 71–77, 2007.
- E. Louie, S. Nik, J.-S. Chen et al., “Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation,” Breast Cancer Research, vol. 12, no. 6, article R94, 2010.
- Y. Shimono, M. Zabala, R. W. Cho et al., “Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells,” Cell, vol. 138, no. 3, pp. 592–603, 2009.
- BO. Wang, M. Herman-Edelstein, P. Koh et al., “E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-β,” Diabetes, vol. 59, no. 7, pp. 1794–1802, 2010.
- Y. Xiong, J. H. Fang, J. P. Yun et al., “Effects of microrna-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma,” Hepatology, vol. 51, no. 3, pp. 836–845, 2010.
- J. Krol, I. Loedige, and W. Filipowicz, “The widespread regulation of microRNA biogenesis, function and decay,” Nature Reviews Genetics, vol. 11, no. 9, pp. 597–610, 2010.
- H. Siomi and M. C. Siomi, “Posttranscriptional regulation of microRNA biogenesis in animals,” Molecular Cell, vol. 38, no. 3, pp. 323–332, 2010.
- H. I. Suzuki and K. Miyazono, “Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway,” Journal of Molecular Medicine, vol. 88, pp. 1085–1094, 2010.
- B. N. Davis-Dusenbery and A. Hata, “Mechanisms of control of microRNA biogenesis,” Journal of Biochemistry, vol. 148, no. 4, pp. 381–392, 2010.
- M. A. Newman and S. M. Hammond, “Emerging paradigms of regulated microRNA processing,” Genes and Development, vol. 24, no. 11, pp. 1086–1092, 2010.
- Y. Lee, M. Kim, J. Han et al., “MicroRNA genes are transcribed by RNA polymerase II,” EMBO Journal, vol. 23, no. 20, pp. 4051–4060, 2004.
- G. M. Borchert, W. Lanier, and B. L. Davidson, “RNA polymerase III transcribes human microRNAs,” Nature Structural and Molecular Biology, vol. 13, no. 12, pp. 1097–1101, 2006.