Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum
Figure 4
Docking of peptides into the noncovalent pfTopoI-DNA complex. Side view of the ternary pfTopoI-DNA-peptide complex. The structure represents the best complex obtained from the docking experiment. The protein is shown in red cartoon, the DNA in grey ribbon and the peptide in licorice, with the atoms coloured with the following code: carbon: cyan, nitrogen: blue, oxygen: red, sulphur: yellow. (a) Octapeptide WRWYCRCR, (b) hexapeptide WYCRCR, and (c) hexapeptide KCCRCR.
