RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?

Figure 1

Cartoon depicting the interactions of RASSF1A and RASSF1C. RASSF1A and RASSF1C share a common C-terminal aminoacid sequence, which includes the ATM phosphorylation site (red asterisk), the RA domain, and the SARAH domain but differs at the N-terminal. RASSF1A has a C1 domain which interacts with MOAP-1 and MDM2. RASSF1C lacks the C1 domain but has an alternative DAXX interaction domain. Serine 131 of RASSF1A has been shown to be mutated from serine (S) to phenylalanine (F). An alanine (A) to Serine (S) polymorphism also exists at the 133 site.