Three-Dimensional Molecular Modeling of a Diverse Range of SC Clan Serine Proteases

Figure 1

Superposed structures of X-ray and modeled structures of the selected proteases of the SC clan. Structures of the plant (PM0078228, Arabidopsis thaliana, purple) and protozoan (PM0078229, Plasmodium falciparum, yellow) SC proteases were superposed with the animal (1QFS, Sus scrofa, red), archaeon (1VE7, Aeropyrum pernix, magenta), fungal (1WPX, Saccharomyces cerevisiae, cyan), and bacterial (2BKL, Myxococcus xanthus, orange) X-ray structures. The catalytic triad residues (Ser, Asp, His; CBP2 residue numbering used as a standard reference) are shown in ball and stick models, and the core regions of the structures are indicated by the white circle.