The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents

Table 2

Concentrations of CTP, GTP, ATP, UTP in activated or resting primary human macrophages versus lymphocytes. Concentrations of rNTPs are only 4–7-fold lower in macrophages versus lymphocytes independent of activation state [18, 25]. ±indicates standard deviation. Data represents at least five independent experiments performed with pooled cells from six independent donors.

	CTP	GTP	ATP	UTP
	𝜇M
Activated lymphocytes	182±24	1,745 ± 128	6,719 ± 560	690±100
Activated macrophages	27±8	303±60	1,011 ± 247	141±17
Fold difference between activated lymphocytes versus activated macrophages	7	6	7	5
Resting lymphocytes	111±30	923±234	4,753 ± 896	453±174
Resting macrophages	25±8	323±95	1,124 ± 339	173±47
Fold difference between resting lymphocytes versus resting macrophages	4	3	4	3