Table of Contents
Molecular Biology International
Volume 2012, Article ID 643856, 4 pages
http://dx.doi.org/10.1155/2012/643856
Research Article

Relative Copy Number Variations of CYP2C19 in South Indian Population

1Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
2Onco-Hematology Unit, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
3U 763, INSERM, Hopital Robert Debre, Paris, France

Received 29 March 2012; Accepted 28 April 2012

Academic Editor: George A. Calin

Copyright © 2012 Anichavezhi Devendran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently. The observations in the recent reports on the influence of promoter region variants on the metabolism of CYP2C19 substrates might also have been influenced by the copy number variations of CYP2C19. In this paper, we describe copy number variations of CYP2C19 using real-time polymerase chain reaction by comparative Ct method. No copy number variations were observed in the south Indian population indicating the observed discrepancies in genotype-phenotype association studies might be due to the regulatory region polymorphisms as reported earlier.