Molecular Biology International / 2012 / Article / Tab 2

Research Article

Prevention of Lysosomal Storage Diseases and Derivation of Mutant Stem Cell Lines by Preimplantation Genetic Diagnosis

Table 2

Polymorphic microsatellite markers used in PGD/LSD analyses.

DiseaseMarkers

Tay SachsD15S204, D15S110, D15S197, TS-AT3 (chr15: 70157048-70157297), TS-TATT (chr15: 70231314-70231376), TS-TTTC (chr15: 70404391-70404690), TS-TC (chr15: 70408504-70408653), TS-ATCT (chr15: 70417649-70417798), TS-CA (chr15: 70420187-70420336), TS-TA (chr15: 70465534-70465733), TS-TG (chr15: 70172306-70172338), D15S215, D15S188, D15S169, D15S818

Gaucher disease type 1D1S2715, D1S2858, D1S305, Gau-GT2 (chr1: 153399641-153399790), Gau-AC (chr1: 153726984-153727183), Gau-GT (chr1: 153425519-153425668), Gau-TTAT (chr1: 153461596-153461795), Gau-AAAG (chr1: 153462605-153462854), Gau-AAT (chr1: 153480717-153480916), Gau-TAT (chr1: 153519755-153519904), GAu-AAT2, (chr1: 153527305-153527554), D1S1153, Gau-AC3 (chr1: 153593444-153593643), D1S27777, Gau-AC4 (chr1: 153897882-153898031), D1S303, D1S2140, D1S2721, D1S2624

Mucopolysaccharidosis IIDXS731, DXS1215, DXS1691, DXS8091, DXS6687, DXS2496, DXS1185, DXS1193, DXS457, DXS1123, Hunter-GAGG (chrX: 148394342-148394541), Hunter-AC (chrX: 148405052-148405251), DXS8086, DXS8377, DXS8069, DXS7423, DXS8011

Fabry disease 
(sex selection markers)
AmelogB96, SRY, DXS1254, DXS998, DXS1215, DXYS154, DXS566, DXS8377

Polymorphic microsatellite markers used in PGD/LSD analyses: location of markers is based on human USCS genome browser assembly March 2006, NCBI36/hg18 presented in the order of location on the chromosome (http://genome.ucsc.edu/cgi-bin/hgGateway?hgsid=319485427&clade=mammal&org=Human&db=hg18).
The markers that do not have standard DS nomenclature were named arbitrarily and their physical chromosome and basepair location are indicated.

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