Table of Contents
Molecular Biology International
Volume 2012, Article ID 868597, 6 pages
http://dx.doi.org/10.1155/2012/868597
Review Article

The Role of TNPO3 in HIV-1 Replication

Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park, Price Center 501, New York, NY 10461, USA

Received 19 March 2012; Revised 4 June 2012; Accepted 5 June 2012

Academic Editor: Abraham Brass

Copyright © 2012 Felipe Diaz-Griffero. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

TNPO3, transportin-SR2 or Tnp3, a member of the karyopherin β superfamily of proteins, is important for the ability of human immunodeficiency virus (HIV-1) to achieve productive infection, as TNPO3 depletion in human cells leads to a dramatic reduction of infection. Here we describe and discuss recent findings suggesting that TNPO3 assists HIV-1 replication in the nucleus and in fact that TNPO3 may assist PIC maturation in the nucleus. In addition, the viral determinant for the requirement of TNPO3 in HIV-1 infection is discussed. This paper summarizes the most significant recent discoveries about this important host factor and its role in HIV-1 replication.