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Programs | Purpose | Tools or procedures of evaluation | Input | Output | Internet accessibility | References |
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Epitope prediction |
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MimoDB 2.0 | Mimotope database | MySQL relational database | according to menu | Structures visualization, alignments, and so forth | http://immunet.cn/mimodb/ | [105] |
MimoPro | Maps a group of mimotopes back to a source antigen so as to locate the interacting epitope on the antigen | Branch and bound optimization (analysis of overlapping patches on the surface of a protein) | PDB identifier mimotope sequences | Score + 3D location in antigen | http://informatics.nenu.edu.cn/MimoPro/ | [108] |
ViPR | Virus pathogen database | Integration of various resources | according to menu | Structures, annotations, and so forth | http://www.viprbrc.org/ | [140] |
MetaMHC | Prediction of MHC binding epitopes | meta-approach | QS | Four metapredictor scores including MetaSVMp score | http://www.biokdd.fudan.edu.cn/Service/MetaMHC.html | [141] |
Epitopia | Prediction of B-cell epitopes |
*MLA *MLA + 3D + SA |
*QS *PDB ACF | Immunogenicity score + probability score + color scale record on QS | http://epitopia.tau.ac.il | [115] |
ElliPro | New structure-based tool for the prediction of antibody epitopes | 3D + SA + flx + antigenicity |
*QS *PDB ACF | Score + visualized epitope 3D structure and 3D location | http://tools.immuneepitope.org/tools/ElliPro | [114] |
MHCPred | Prediction of class II mouse MHC peptide binding affinity | ISC-PLS, SYBYL software package | QS | Binding affinity (pIC50) | http://www.jenner.ac.uk/MHCPred | [129] |
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Stable epitopes and vaccines |
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BayesB | SVM-based prediction of linear B-cell epitopes using Bayes Feature Extraction | Residue conservation + position-specific residue propensities | QS | Residue epitope propensity score | http://www.immunopred.org/bayesb/index.html | [120] |
OptiTope | Selection of optimal peptides for epitope-based vaccines | Multistep parallel evaluation | MSA of Ag list of ES table: ES, ES related MHC | Fraction of overall immunogenicity covered MHC | http://www.epitoolkit.org/optitope | [142] |
PVS | PVS returns a variability-masked sequence, which can be submitted to the RANKPEP server to predict conserved T-cell epitopes. | 3D visualization of MSA derived sequence variability “per site” | PDB ACF | 3D map of variability fragments with no variable residues and their 3D location in antigen | http://imed.med.ucm.es/PVS/ | [143] |
PEPVAC | Prediction of MHC I; server can also identify conserved and promiscuous MHC I ligands | PSSM, distance matrix, phylogenic clustering algorithm | Genome, HLA-supertypes | Selected peptide sequences score | http://immunax.dfci.harvard.edu/PEPVAC/ | [144] |
RANKPEP | Prediction of MHC I and MHC II ligands | Profile comparison | Genome, HLA-supertypes, QS | Selected peptide sequences score | http://www.mifoundation.org/Tools/rankpep.html | [145, 146] |
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