Research Article

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis

Figure 2

T47D breast (a) and H1299 lung (b) cancer cells stably overexpressing RASSF1A or RASSF1C were assayed for cell viability/proliferation in absence of TNF-α using the Alamar Blue assay. RASSF1A overexpression significantly reduced while RASSF1C overexpression significantly enhanced cell viability/proliferation compared to control (BB) cells. Data is representative of at least 3 independent experiments and the values represent the mean ± SEM. * for 1C compared to 1A and BB and for 1A compared to BB.