Table of Contents
Molecular Biology International
Volume 2013 (2013), Article ID 145096, 9 pages
http://dx.doi.org/10.1155/2013/145096
Research Article

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis

1Surgical Oncology Laboratory, Loma Linda VA Medical Center, Loma Linda, CA 92357, USA
2Department of Surgery, Loma Linda University, Loma Linda, CA 92357, USA
3Musculoskeletal Disease Center, Loma Linda VA Medical Center, Loma Linda, CA 92357, USA

Received 22 July 2013; Accepted 25 September 2013

Academic Editor: Emanuel Strehler

Copyright © 2013 Mark E. Reeves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Dammann, C. Li, J. H. Yoon, P. L. Chin, S. Bates, and G. P. Pfeifer, “Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3,” Nature Genetics, vol. 25, no. 3, pp. 315–319, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. D. G. Burbee, E. Forgacs, S. Zöchbauer-Müller et al., “Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression,” Journal of the National Cancer Institute, vol. 93, no. 9, pp. 691–699, 2001. View at Google Scholar · View at Scopus
  3. R. Dammann, T. Takahashi, and G. P. Pfeifer, “The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas,” Oncogene, vol. 20, no. 27, pp. 3563–3567, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. M. D. Vos, C. A. Ellis, A. Bell, M. J. Birrer, and G. J. Clark, “Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis,” The Journal of Biological Chemistry, vol. 275, no. 46, pp. 35669–35672, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Dammann, C. Li, J. H. Yoon, P. L. Chin, S. Bates, and G. P. Pfeifer, “Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21. 3.,” Nature Genetics, vol. 25, no. 3, pp. 315–319, 2000. View at Google Scholar
  6. M. E. Reeves, S. W. Baldwin, M. L. Baldwin et al., “Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis,” BMC Cancer, vol. 10, article 562, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. G. Amaar, M. G. Minera, L. K. Hatran, D. D. Strong, S. Mohan, and M. E. Reeves, “Ras association domain family 1C protein stimulates human lung cancer cell proliferation,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 291, no. 6, pp. L1185–L1190, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Reeves, M. L. Baldwin, R. Aragon et al., “RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1,” BMC Research Notes, vol. 5, article 239, 2012. View at Publisher · View at Google Scholar
  9. M. E. Reeves, R. J. Aragon, M. Alfakhouri et al., “Ras-association domain family 1C protein enhances ereast tumor growth in vivo,” Cancer Growth and Metastasis, vol. 5, pp. 27–33, 2012. View at Publisher · View at Google Scholar
  10. E. Estrabaud, I. Lassot, G. Blot et al., “RASSF1C, an isoform of the tumor suppressor RASSF1A, promotes the accumulation of β-catenin by interacting with βTrCP,” Cancer Research, vol. 67, no. 3, pp. 1054–1061, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Pelosi, C. Fumagalli, M. Trubia et al., “Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung,” Anticancer Research, vol. 30, no. 10, pp. 4269–4281, 2010. View at Google Scholar · View at Scopus
  12. G. Malpeli, E. Amato, M. Dandrea et al., “Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors,” BMC Cancer, vol. 11, article 351, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. C. J. Foley, H. Freedman, S. L. Choo et al., “Dynamics of RASSF1A/MOAP-1 association with death receptors,” Molecular and Cellular Biology, vol. 28, no. 14, pp. 4520–4535, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. D. Vos, A. Dallol, K. Eckfeld et al., “The RASSF1A tumor suppressor activates bax via MOAP-1,” The Journal of Biological Chemistry, vol. 281, no. 8, pp. 4557–4563, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Guo, X. Zhang, and G. P. Pfeifer, “The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2,” The Journal of Biological Chemistry, vol. 286, no. 8, pp. 6253–6261, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Avruch, M. Praskova, S. Ortiz-Vega, M. Liu, and X. F. Zhang, “Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases,” Methods in Enzymology, vol. 407, pp. 290–310, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. H. J. Oh, K.-K. Lee, S. J. Song et al., “Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis,” Cancer Research, vol. 66, no. 5, pp. 2562–2569, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Yi, J. Yang, X. Chen et al., “RASSF1A suppresses melanoma development by modulating apoptosis and cell-cycle progression,” Journal of Cellular Physiology, vol. 226, no. 9, pp. 2360–2369, 2011. View at Publisher · View at Google Scholar · View at Scopus