Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence

Table 6

Association between mEPHX gene variants and histologic type of brain tumor.

Histologic type	Meningioma	Astrocytoma	H. adenoma	Other
Exon 3	30 (29%)	39 (38%)	9 (9%)	24 (24%)
Tyr/Tyr	19 (63%)	23 (59%)	5 (55%)	11 (46%)
Tyr/His, His/His	11 (37%)	16 (41%)	4 (45%)	13 (54%)
𝜒^2	0.4	0.05	0.01	0.9
𝑃 value	0.5	0.8	1.0∗	0.3
OR (95% CI)	0.7 (0.3–1.9)	0.9 (0.4–2.0)	1.0 (0.2–4.8)	1.5 (0.5–4.1)
Exon 4	32 (30%)	39 (37%)	9 (9%)	25 (24%)
His/His	27 (84%)	33 (85%)	9 (100%)	16 (64%)
His/Arg, Arg/Arg	5 (16%)	6 (15%)	—	9 (36%)
𝜒^2	0.2	0.3	2.1	3.3
𝑃 value	0.7	0.6	0.3∗	0.1
OR (95% CI)	0.7 (0.2–2.5)	0.7 (0.2–2.2)	—	2.4 (0.8–6.8)

∗Fisher exact.