Table of Contents
Molecular Biology International
Volume 2014, Article ID 375325, 7 pages
http://dx.doi.org/10.1155/2014/375325
Review Article

Cancer Stem Cells Accountability in Progression of Head and Neck Squamous Cell Carcinoma: The Most Recent Trends!

Department of Oral Pathology & Microbiology, Institute of Dental Sciences, SOA University, K-8, Ghatikia, Bhubaneswar, Odisha-751003, India

Received 2 November 2013; Revised 2 January 2014; Accepted 13 January 2014; Published 19 February 2014

Academic Editor: Malayannan B. Subramaniam

Copyright © 2014 Samapika Routray and Neeta Mohanty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cancer stem cells (CSCs) play a major role in local recurrence and metastatic spread in head and neck squamous cell carcinomas (HNSCC). Evidence suggests that cancer stem cells are resistant to conventional therapy. So the emerging concepts of the role of cancer stem cells in the pathobiology of HNSCC should be understood carefully to be able to create new paradigms in treatment plans.