Review Article

Cancer Stem Cells Accountability in Progression of Head and Neck Squamous Cell Carcinoma: The Most Recent Trends!

Table 1

Molecular markers implicated in HNSCC cancer stem cell detection.

ReferenceStem cell markerCancer cell lines studied

Barth et al., 2004 [35]CD34, CD117 (receptor of stem cell factor, SCF)Oral cavity, pharynx, and larynx (stromal fibrocytes)
Kojc et al., 2005 [36] CD34, transforming growth factor beta 1 (TGF beta 1) Larynx
Tan et al., 2006 [37]Stem cell factorNasopharynx (plasma)
Prince et al., 2007 [32]CD44, BMI 1HNSCC generated in immunodeficient mouse model
Zhou et al., 2007 [38]CD133HNSCC cell lines (hep-2)
Pries et al., 2008 [39]CD44Hypopharynx, larynx, and oropharynx
Chiou et al., 2008 [40]Oct-4, Nanog, and CD133Oral squamous cell carcinoma stem like cells
Chen et al., 2009 [41]Bmi-1 1, Pakt (+) CD133, CD44, Nanog, and Oct-4 (−)Tongue (SASVO3)
Chen et al., 2009 [34]Aldehyde dehydrogenase 1 (ALDH)Immunodeficient mouse model
Y. Wu and P. Y. Wu, 2009 [42]CD133Head and neck squamous cell carcinoma
Krishnamurthy et al., 2010 [43]Aldehyde dehydrogenase (ALDH)Head and neck squamous cell carcinoma