Table of Contents
Molecular Biology International
Volume 2014 (2014), Article ID 630797, 24 pages
http://dx.doi.org/10.1155/2014/630797
Review Article

The Role of Suppressors of Cytokine Signalling in Human Neoplasms

1St George’s Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK
2The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, UK

Received 11 October 2013; Revised 2 February 2014; Accepted 4 February 2014; Published 16 March 2014

Academic Editor: József Szeberényi

Copyright © 2014 Walid Sasi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour suppressors and dysregulation of their biological roles in controlling cytokine and growth factor signalling may contribute to the development of many solid organ and haematological malignancies. This review explores their biological functions and their possible tumour suppressing role in human neoplasms.