The Role of Suppressors of Cytokine Signalling in Human Neoplasms

Figure 4

Versatility of SOCS protein functions. The different domains of SOCS proteins mediate distinct interactions and functions. Some of these are specific for certain SOCS family members such as the KIR-dependent inhibition of JAK activity by SOCS1 and SOCS3 and SOCS box-dependent substrate recognition in case of CIS. Other functions are more general such as competition for shared receptor motifs and Elongin B/C recruitment. The SOCS box is involved in as diverse as receptor interaction, adaptor coupling, target degradation, and control of SOCS protein stability.