Review Article
The Role of Suppressors of Cytokine Signalling in Human Neoplasms
Table 1
Cytokine activation of janus kinases (JAKs).
| | Cytokine receptor | Associated JAK(s) |
| | Interferons | | | IFN | JAK1 [8] and JAK2 [9] | | IFN | JAK1 [9, 10] and JAK2 [9, 10] | | IL-10 | JAK1 [11] and TYK2 [11] | | IL-6 | JAK1 (IL-6R chain and gp130) [12] | | Shared receptor (IL-2, IL-4, IL-7, IL-9, and IL-15) | JAK1 [13] and JAK3 [13] | | Shared receptor (IL-3, IL-5, and GM-CSF) | JAK2 [14] | | Homodimer receptors (GH, EPO, prolactin, and TPO) | JAK2 [15] |
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Abbreviations: GM-CSF: granulocyte monocyte colony stimulating factor; EPO: erythropoietin; TPO: thrombopoietin.
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