The Role of Suppressors of Cytokine Signalling in Human Neoplasms

Table 2

SOCS family members associate with a variety of signalling proteins and inhibit signalling by many cytokines.

Name	Induced and/or Inhibits signalling by	Associates with
CIS	IL-2 [37, 38]; IL-3 [31, 39]; IL-6 [23]; IL-9 [40]; IL-10 [41]; PRL [42–44]; EPO [39]; IGF-I [45]; GH [37, 46, 47]; TPO [23, 48]; G-CSF [49]; GM-CSF [31, 39]; IFN𝛼 [50]; IFN𝛾 [23]; TNF𝛼 [23]; Leptin [51]; TSLP [52]; CNTF [53]	IL-2 R [38]; IL-3 R [31]; EPO R [31]; GH R [47], [54]; PCKθ [55]; TCR [55]
SOCS1	IL-2 [24, 56]; IL-3 [24]; IL-4 [32, 57, 58]; IL-6 [23, 32]; IL-13 [59]; GH [47, 54, 60]; PRL [42]; EPO [23, 24]; LIF [32]; IFN𝛾 [23, 61]; IFN𝛼/𝛽 [61, 62]; OSM [23]; TSLP [52]; TPO [23]; IGF-I [45]; G-CSF [32]; CNTF [53]; TNF𝛼 [63]; LPS [64, 65]; INS [66]; TSH [67]; CpG DNA [68]	JAK1 [24]; JAK2 [24, 28]; JAK3 [24]; GRB2 [69]; VAV [69]; FGF R [33]; PYK2 [33]; GH R [47, 54, 60]; KIT R [33, 69]; FLT3 R [69]; IGF-I R [45, 70], INF𝛼 R [61]; INF𝛾 R [61]; EPO R [24]; PRL R [42, 44], LIF R [32]; TNF𝛼 R [63]; IL-2 R [24, 56]; IL-3 R [24]; IL-4 R [57]; IL-6 R [32]; Il-7 R [71]; IL-12 R [72]; Il-15 R [73]; TPO R [23]; TSLP R [52]; OSM [23]; Leptin R [74]; TLR [75]; INS R [76]
SOCS2	IL-1𝛽 [77]; IL-2 [78, 79]; IL-3 [23, 79]; IL-4 [23]; IL-6 [77, 80]; IL-15 [81]; GH [47, 60]; PRL [42]; LIF [23, 78]; IGF-I [45, 70]; EPO [23, 82]; EGF [83]; GM-CSF [23]; G-CSF [23]; IFN𝛼 [50]; IFN𝛾 [23, 77]; CNTF [53]; INS [66]	IGF-I R [70]; PRL R [42]; GH R [47, 54]
SOCS3	IL-1𝛽 [84]; IL-2 [78, 85]; IL-3 [78, 86]; IL-4 [57]; IL-6 [87–89]; IL-9 [40]; IL-10 [41]; IL-11 [90]; IL-13 [23]; IL-22 [91]; GH [23, 47, 54, 60, 92]; PRL [42]; EPO [93, 94]; TPO [95]; LIF [60, 96]; IFN𝛼 [61]; IFN𝛾 [61]; G-CSF [23]; GM-CSF [97]; TNF𝛼 [98]; IGF-I [45, 66]; EGF [99, 100]; PDGF [99]; BFGF [101]; TSH [67]; CNTF [53]; Leptin [51, 102–104]; OSM [61, 105]; INS [66, 104, 106]; CT1 [107]	IL-1𝛽 R [108]; IL-2 R [85]; IL-4 R [57]; IL-6 R [96]; IL-9 R [40]; IL-11 R [90]; IL-23 R [109]; IL-27 R [110]; PRL R [42, 44]; LIF R [60]; IFN𝛼/𝛽 R [61]; IFN𝛾 R [61]; G-CSF R [111]; LCK [33]; FGF 𝑅 [33]; PYK2 [33]; GH R [47, 54, 60]; EPO R [93]; Leptin R [102, 112]; gp130 [93, 113–115]; IGF-I R [45, 70, 116]; CNTF R [53]; OSM R [105]; INS R [104]; CT1 R [107]; CD28 [117]; Calcineurin [118]
SOCS4	EGF [119]; LIF [120]	EGF R [29, 119, 121]; JAK2 [29]; C-KIT [29]
SOCS5	IL-6 [96]; EGF [119]	IL-4 R [122]; IL-6 R [96]; EGF R [119, 121]; LIF R [96]
SOCS6	IGF-I [123]; INS [124]; FLT3 [125]; SCF [126]	IGF-I R [123]; INS R [124]; FLT3 R [125]; SCF R [126]; TCR [127]
SOCS7	GH [77, 128]; PRL [77, 128]; IGF-I [129]; INS [129]; EGF [27]; Leptin [128]	GH R [128]; PRL R [128]; INS R [129, 130]; IRS-1 [130]; IRS-2 [129]; IRS-4 [129]; PI3K (p85) [129]; Grb2 [27]; EGF R [27]; Leptin R [128]; Ash [27]; Nck [27, 131]; PLC𝛾 [27]

Abbreviations: R: receptor; PKC: protein kinase C; OSM: oncostatin M; Tpo: thrombopoietin; BFGF: basic fibroblast growth factor; CNTF: ciliary neurotrophic factor; CT1: cardiotrophin-1; TSLP: thymic stromal lymphopoietin; TCR: T cell receptor; INS: insulin; SCF: stem cell factor.