Table of Contents
Molecular Biology International
Volume 2014 (2014), Article ID 686984, 14 pages
http://dx.doi.org/10.1155/2014/686984
Review Article

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions

Department of Biotechnology and Bioinformatics, University of Kashmir, Science Block, Ground Floor, Srinagar, Jammu and Kashmir 190006, India

Received 22 August 2014; Accepted 6 October 2014; Published 20 November 2014

Academic Editor: Malayannan B. Subramaniam

Copyright © 2014 Mehvish Showkat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

mTOR is a central nutrient sensor that signals a cell to grow and proliferate. Through distinct protein complexes it regulates different levels of available cellular energy substrates required for cell growth. One of the important functions of the complex is to maintain available amino acid pool by regulating protein translation. Dysregulation of mTOR pathway leads to aberrant protein translation which manifests into various pathological states. Our review focuses on the role mTOR signaling plays in protein translation and its physiological role. It also throws some light on available data that show translation dysregulation as a cause of pathological complexities like cancer and the available drugs that target the pathway for cancer treatment.